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Although cytosolic CPS2 can produce a cytosolic pool of carbamoyl phosphate, CPS1 is a major rate-limiting enzyme in pyrimidine biosynthesis using nitrogen released via mitochondrial glutaminolysis 32

[79] reported that selenium could upregulate mitofusin-1 (Mfn1) expression to promote mitochondrial fusion, thereby alleviating ferroptosis and attenuating brain ischemia-reperfusion injury in mice

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